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Monitor Intently (one)pentobarbital will decrease the extent or outcome of fentanyl transdermal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Carefully. Coadministration of fentanyl with CYP3A4 inducers could lead to a lower in fentanyl plasma concentrations, deficiency of efficacy or, quite possibly, devel